This research is supported by national funds through FCT (Fundação para a Ciência e a Tecnologia) and by European funds of FEDER (Fundo Europeu de Desenvolvimento Regional), within the COMPETE 2020 (Programa Operacional Factores de Competitividade) under project POCI-01-0145-FEDER-029283; PTDC/ASP-PLA/29283/2017